The Prime Family Manuscript Collection contains materials associated with a number of family members dating from as early as the 1720s to as late as the 1890s. The bulk of the content, however, relates to Ebenezer, Nathaniel Scudder, and Samuel Irenaeus Prime. The collection holds hundreds of sermons written by these individuals as well as letters, ministerial records, legal documents, notebooks, manuscripts, and family histories.

This collection consists of eight sermons dated 1840-1851.

This collection includes correspondence records, lecture notes, and sermon notes (1844) ; Lecture notes from Archibald Alexander’s introductory lecture on "Hints for young men" and Samuel Miller’s "Remarks" ; and notes on sermons by Archibald Alexander, Joseph Addison Alexander and Charles Hodge.

This collection consists of four volumes of manuscript sermons.